β-Phenyl-β-Alanine Prevents the Activation of Vagal Efferent Discharges Evoked by Baclofen and GABA in Rats

[摘要] References(10)Cited-By(3)The effects of DL-β-phenyl-β-alanine (BPBA) on vagal efferent discharges elicited by γ-aminobutyric acid (GABA) and baclofen were investigated in rats. When given alone, BPBA (40 mg/kg, i.v.) caused no significant change in vagal nerve response and did not elicit any convulsions. Pretreatment with BPBA (40 mg/kg, i.v.) resulted in 70% and 80% reductions in the vagal efferent discharges induced by GABA (400 mg/kg, i.v.) and baclofen (4 mg/kg, s.c.), respectively. The present results suggest that BPBA may be a novel GABA antagonist with respect to vagal activation mechanisms in the CNS.

[学科分类] 药理学

[关键词] GABA;Baclofen;β-Phenyl-β-alanine (BPBA)