DIFFERENCES AMONG DIPYRIDAMOLE, CARBOCHROMEN AND LIDOFLAZINE IN RESPONSES OF THE CORONARY AND THE RENAL ARTERIES

[摘要] References(18)Cited-By(5)Chemical compounds which are used as coronary vasodilators in the clinic may be divided into specific and non-specific groups. Dipyridamole (1), carbochromen (2) and lidoflazine (3) belong to the former, while nitroglycerin and papaverine derivatives are typical drugs belonging to the latter. Since Bretschneider (4) discovered in 1962 that dipyridamole potentiated hypotensive response to adenosine, extensive studies have been published as to the effect of dipyridamole on adenosine metabolism. Miura et al. (5) observed a marked potentiation of adenosineinduced coronary vasodilation after dipyridamole treatment. On the other hand, Hashimoto et al. (6) described that dipyridamole induced a vasoconstriction in the renal artery similar to the effects of AMP or adenosine. Sakai et al. (7) found that in the renal artery dipyridamole potentiated vasoconstrictor response not only to adenosine and AMP but also to norepinephrine. Recently, the authors (8) confirmed a potentiation of coronary vasodilator response to norepinephrine after dipyridamole treatment. In this paper, the effects of dipyridamole, carbochromen and lidoflazine on the renal and the coronary vessels have been compared. A constant volume perfusion was arranged and the change in perfusion pressure was recorded. Drug solution, 0.1 ml was injected intra-arterially in a period of 10 sec.. The continuous administration of drug solution was performed using a Harvard infusion pump (Model 600/900). Dipyridamole was infused at a rate of 0.01 and 0.1 μg/min and carbochromen or lidoflazine was infused at the rate of 0.1 and 1.0 μg/min.

[学科分类] 药理学