CHANGES IN SENSITIVITY TO CONVULSION IN MICE WITH OLFACTORY BULB ABLATION

[摘要] References(34)Cited-By(8)Since bilateral ablations of the olfactory bulb were found to induce characteristic hyperemotionality in the rat (1-5), this behavior, particularly aggressiveness, has come to be used for evaluating the taming effect of tranquilizing agents, though the neural mechanisms underlying this abnormal behavior have remained unknown (6). It would be worthwhile to know the changes in drug sensitivity of such abnormal animals, even from the ceinical point of view, and the effects of psychotropic drugs are known to be different qualitatively, as well as quantitatively, depending on the disease. Studies concerning the changes in drug sensitivity in abnormal animals with such brain lesions have so far been few (7-11). Recently, Malick et al. (12) compared the efffects of psychoactive agents on three models of aggression induced by lesioning of the septum, the ventromedial hypothalamus and the olfactory bulb in rats, and found significant differences in potencies of these drugs among these models with lesions in different brain areas. Questions may arise as to whether or not these potency differences are also relevant to effects other than anti-aggressive action, and as to whether the drug sensitivities of these models are different from that of intact animals, as aggressiveness is rarely observed in normal laboratory rats. This investigation was therefore undertaken to determine changes, if any, in sentisivity to electroshock- and drug-induced convulsions in mice with bilateral olfactory bulb ablations, since convulsions could be measured quantitatively and compared between the intact and abnormal animals with brain lesions.

[学科分类] 药理学