EFFECTS OF SEVERAL MACROLIDE ANTIBIOTICS ON BLOOD PRESSURE OF DOGS

[摘要] References(10)Cited-By(5)Among research reports on antibiotics, clinical reports on the treatment of infection occupy an overwhelming majority. In basic animal experiments, studies of antibiotics on antibacterial activity, concentration of antibiotics in the blood and distribution in the organs have received almost all of the attention, while studies on the pharmacological actions have apparently been neglected. One of the main reasons for this has been that the toxicity of antibiotics is far milder than that of most other synthetic drugs, and also because there is seldom any cardiovascular action at the usual therapeutic dosages. Recently the side effects resulting from large doses of antibiotics have presented various problems. The toxicity and pharmacological actions of the antibiotics, however still remain to be clarified. In 1955, Bushby et al. (1) reported the participation of a histamine liberating action in the side effects of polymixin B, pointing out for the first time the presence of histamine-like releasers among antibiotics. In 1970, Matsumoto (2) reported the histamine liberating action in colistin derivertives of the same series. In the present study, the effects of four representative macrolide antibiotics: erythromycin, oleandomycin, spiramycin and leucomycin were studied to examine depressor effects on the blood pressure of dogs.

[学科分类] 药理学