ANTI-NOCICEPTIVE ACTIVITY OF CLONIXIN IN RHESUS MONKEYS

[摘要] References(9)Cited-By(4)Clonixin (Sch 10304) [2-(2' methyl-3' chloro anilino) nicotinic acid] has been reported to be an orally effective analgesic and a non-steroidal anti-inflammatory agent in rodents (1). Clonixin has no dependence liability in monkeys (2) and its analgesic effect is not antagonized by naloxone in mice and rats (3). Clinical results with clonixin have shown degrees of analgesic effects not usually observed with non-narcotic agents. Single oral doses of clonixin ranging from 300-600 mg produced pain relief comparable to that seen with parenteral administration of morphine (4). Procedures employing electric shock in monkeys have been used by other investigators for analgesic assessment (5-7). Thus far, only narcotic and narcotic antagonist analgesics have been shown to be effective in this procedure. This investigation describes the analgesic properties of clonixin on behavior maintained by nociceptive electric shock in Rhesus monkeys (Macaca mulatta) using a shock-escape procedure.

[学科分类] 药理学