MECHANISM OF THE ANTIRHEUMATIC EFFECT OF SALICYLATES AND CINCHOPHEN

[摘要] References(10)Now that the modern effective drugs like cortison and ACTH are available for treatment of the rheumatic disorders, salicylates and cinchophen which were the most effective drugs for these disorders before their appearance have been turned in the background. However, their effect is so specific that they were used even for the diagnosis of the rheumatism, although their mechanism of action was not clarified. We thought the pituitary-adrenal system may be involved in this activity of salicylates and cinchophen, and they may act through release of cortison and other hormones from the adrenal cortex. Therefore, we studied changes of the number of circulating eosinophils, urinary excretion of the reducing steroids, and creatinine-uric acid ratio of the urine, following administration of salicylates and cinchophen in normal and adreralectomized rats. Their relation could finally be established as the results of these researches. However, we have found out later that the same question on the effect of salicylates was also posed by another researchers independently. Namely, Blanchard and coworkers(1), Hetzel and Hine(2) and Cronin and King(3) studied specific effect of salicylates on the adrenal-pituitary system by using the ascorbic acid content of rat adrenals as indicator, and found that the salicylate reduced the ascorbic acid content considerably in normal rats but not in hypophysectomized ones. Van Cauwenberge(4), Bertolani and coworkers(5) and Van Cauwenberge and Heusghem(6) demonstrated reduction of circulating eosinophils and increased urinary excretion of 17-ketosteroids following administration of salicylate. Nevertheless, we want to report our data in the present paper, because there are some difference in ways of experiments and the action of cinchophen was studied besides that of salicylate.

[学科分类] 药理学