THE SITE OF HISTAMINE RELEASE BY SINOMENINE

[摘要] References(16)In the previous report (1), some evidences were given for the release of histamine in plasma and thoracic lymph of a dog in an amount that would be substantially adequate to account for the degree of vascular reaction caused by the intravenous injection of sinomenine in this animal. The present series of experiments were undertaken in order to find from which organ these amounts of histamine had been derived. Since it is already known that in dogs, the majority of histamine released by peptone (2), certain specific histamine releasers including trypanocidal aromatic diamidines (3), and the antigen in anaphylaxis (4, 5), originate in the liver which is assumed to be the shock organ of this animal, actions of peptone were used as the control throughout the present experiments. In part of the present experiments, cats also were used in which the histamine liberation by the above-mentioned releasers is known to occur, not in the liver (6, 7) but in the skin or muscles (3).

[学科分类] 药理学