Effects of Idebenone (CV-2619) on Endogenous Monoamine Release and Cyclic AMP Formation in Diencephalon Slices from Rats

[摘要] References(7)Cited-By(7)The addition of CV-2619 (10-4 M) stimulated the release of endogenous 5-hydroxytryptamine (5-HT) markedly and that of norepinephrine (NE) slightly from slices of rat diencephalon, but it did not affect dopamine (DA) release. The addition of CV-2619 (10-5-10-4 M) or 5-HT (10-6-10-4 M) stimulated cyclic AMP formation in a concentration-dependent manner. Methysergide (10-4 M), a 5-HT receptor blocker, almost completely blocked CV-2619 (10-4 M) and 5-HT (10-4 M)-induced cyclic AMP formation. These results suggest that CV-2619 stimulates cyclic AMP formation via endogenous monoamine, particularly, 5-HT release.

[学科分类] 药理学