β1-Adrenoceptor-Mediated Amylase Release and Cyclic AMP Accumulation in Rat Parotid Gland Tissue

[摘要] References(13)Cited-By(8)The present study was carried out to determine the relationship of β1-and β2-subtype to amylase release and cyclic AMP (cAM P) accumulation in rat parotid tissue. In in vitro experiments, β-adrenergic agents (isoproterenol and dobutamine)-induced amylase release and cAMP accumulation were all completely inhibited by the β1-antagonist metoprolol, but incompletely inhibited by the β2-antagonist butoxamine. The β2-agonist procaterol caused little or no amylase release or cAMP accumulation. Our results suggest that both amylase release and cAM P accumulation in rat parotid tissue may be selectively induced by β1-adrenergic stimulation.

[学科分类] 药理学