Effect of d-Nicotine on the I-Nicotine-Induced Increase in Gastric Acid Secretion in Rats

[摘要] References(9)Cited-By(1)d-Nicotine (1000 μg) applied into the cerebral ventricle of urethane anesthetized rats increased gastric acid secretion. When 50 μg of d-nicotine was concomitantly administered with 5μg of I-nicotine, the I-nicotine-induced increases in gastric secretion was blocked. The appearance of convulsion induced by I-nicotine in mice was also inhibited by pretreatment with d-nicotine. These results suggest that d-nicotine has agonistic and antagonistic actions to I-nicotine in the central nervous system and that its agonistic potency varies with preparations.

[学科分类] 药理学