EFFECTS OF PROSTAGLANDINS ON EXCITATORY TRANSMISSION IN ISOLATED CANINE TRACHEAL MUSCLE

[摘要] References(23)Cited-By(12)Contractile response of the isolated canine tracheal muscle to transmural nerve stimulation was considerably depressed by 10-6 g/ml of prostaglandin Al (PGA1), A2 (PGA2), B2 (PGB2), E1 (PGE1), E2 (PGE2) and F2α (PGF2α), while the response to exogenously administered ACh was only slightly affected by the pretreatment with prostaglandins (PGs). The order of the potency of the depressive effect was as follows; PGE1>PGE2>PGA1>PGA2≈PGB2≈PGF22α. Therefore, if a negative feedback control mechanism through prostaglandins exists in the excitatory transmission in canine tracheal muscle, the PGE series may predominantly operate the mechanism. Indomethacin in a dose of 10-6 g/ml produced a potentiation of the contractile responses to transmural nerve stimulation and to exogenously administered ACh.

[学科分类] 药理学