DEPLETION OF CATECHOLAMINE BY RESERPINE IN THE INNERVATED AND DENERVATED SUBMAXILLARY GLANDS OF RATS

[摘要] References(23)Shimamoto et al. (1-3) in this laboratory have shown that the sympathetic stimulation of the submaxillary gland in dog, though produces a transiently mucinous secretion per se, depresses the profuse watery secretion caused by stimulation of the chorda tympani or intravenous injection of pilocarpine. The submaxillary gland contains a relatively large amount of noradrenaline (4). Yamawaki (5) has shown that the profuse, spontaneous flow of the submaxillary saliva begins to manifest in association with sedation caused by reserpine in an unanesthetized dog, and is abolished by sectioning of the chorda tympani. However, the spontaneous flow of saliva turns to a decrease at the time when the endogenous catecholamines in the brain, heart and adrenal glands are maximally depleted (6). Accordingly, it is obscure whether the spontaneous flow of saliva caused by reserpine is conditioned by the amine depletion in the brain or submaxillary gland. The catecholamine depleting effect of reserpine on the adrenal medulla in the rat is reported to be significantly reduced by the splanchnic denervation (7). In the current experiments the catecholamine depleting effect of reserpine on the innervated and acutely or chronically denervated submaxillary glands in rats was comparatively studied in an attempt to confirm the mode of sympathetic innervation on the reserpine effect. In addition, the changes in the level of the brain noradrenaline caused by reserpine in the intact rats and rats subjected previously to the resection of the superior cervical ganglion were studied in order to know what extent the brain noradrenaline was maintained by the sympathetic nerve originating from the ganglion.

[学科分类] 药理学