BASAL STUDY ON EARLY DIAGNOSIS OF CADMIUM POISONING : CHANGE IN CARBONIC ANHYDRASE ACTIVITY

[摘要] References(20)Cited-By(4)Cadmium chloride solution (contained 146 PPM of Cd) was administered to mice as drinking fluid for 90 days. Carbonic anhydrase activity was unaffected in blood, liver and kidneys 10 days after administration, however, enzymic activity was significantly reduced in all three organs thereafter. Catalase activity was unchanged until day 31, but was significantly reduced in all organs thereafter. Hemoglobin levels remained unchanged after 10 and 20 days administration, but were significantly reduced thereafter.Time course of response of carbonic anhydrase and catalase activities and blood hemoglobin level to CdCl2·21/2H2O in a dose of 10 mg/kg were examined at intervals ranging from 4 to 24 hr after a single s.c. injection. Carbonic anhydrase activity in liver, kidney and blood was significantly decreased every time, however, catalase activity in the above organs as well as the blood hemoglobin level did not change at any time.Whole-body retention of orally administered 115mCdCl2 with or without the carrier was examined at one week intervals for 30 days. Whole-body retention of 115mCd was significantly less in the carrier group than in the carrier-free group. Average Cd uptake for 30 days was 0.56 μg/day in the carrier-free group and 0.1 mg/day in the carrier group. Cd concentration in liver and kidneys on day 31 was 0.04 and 0.15 PPM respectively in the carrier-free group and each 24 PPM in the carrier group.

[学科分类] 药理学