EFFECT OF HISTAMINE, BRADYKININ AND MORPHINE ON ADRENALINE RELEASE FROM RAT ADRENAL GLAND

[摘要] References(12)Cited-By(50)Effects of histamine, bradykinin and morphine on adrenaline secretion from rat adrenal gland were investigated by means of fluorometric determination of adrenaline in adrenal-venous blood specimens. Histamine caused marked secretion of adrenaline at doses of more than 2.5 mg/kg i.v. The histamine-induced adrenaline secretion at a dose of 2.5 mg/kg was depleted to about one half by splanchnicotomy. Hexamethonium (C6) and atropine did not prevent histamine-induced adrenaline output. However, antihistaminics antagonized the action of this compound. Bradykinin caused increase of adrenaline secretion from the adrenal gland. Splanchnicotomy scarcely prevented the action of bradykinin. C6, phenylbutazone, and pyridinolcarbamate did not block the bradykinin-induced adrenaline output. Morphine caused significant increase of adrenaline secretion from the chronically and completely denervated adrenal gland.

[学科分类] 药理学