RELATIONSHIP BETWEEN CNS DEPRESSANT ACTIVITY AND SELECTIVE ENZYME INHIBITION BY QUINAZOLONE SALICYLHYDRAZIDE DERIVATIVES

[摘要] References(12)Cited-By(1)Substituted quinazolone salicylhydrazides exhibiting anticonvulsant activity against pentylenetetrazol and maximal electric shock (MES) seizures were found to potentiate nembutal induced hypnosis in mice. All these compounds were found to inhibit selectively in vitro oxidation of pyruvic acid and α-ketoglutaric acid. The relative electronegativity of the substituents at position 6 of the quinazolone nucleus in no way paralleled their enzyme inhibitory effects.

[学科分类] 药理学