A STUDY OF ANTI-OVULATORY ACTIVITY OF HALOPERIDOL IN RABBITS

[摘要] References(14)Cited-By(2)The effect of haloperidol (2.5 mg/kg i.v.) was studied on the ovulation induced by progesterone (1 mg/kg s.c.); copper acetate (5 mg/kg i.v.) and coitus in adult female rabbits. Progesterone induced ovulation was blocked by prior treatment with haloperidol. On the other hand, it was found to have no effect on copper acetate induced ovulation. Treatment of rabbits with haloperidol before coitus resulted in loss of receptivity in all the rabbits tested. The results of this study indicate that central adrenergic or dopaminergic mechanisms are involved in progesterone induced ovulation and copper acetate may be acting directly at median eminence to bring about the release of LHRF. The precoital administration of haloperidol in female rabbits resulted in loss of receptivity.

[学科分类] 药理学