PHARMACOLOGICAL STUDIES OF NEUTRAL SAPONINS (GNS) OF PANAX GINSENG ROOT

[摘要] References(19)Cited-By(29)Pharmacological studies of neutral saponins (GNS) of Panax Ginseng root, were performed. GNS showed CNS-depressant action in inhibition of spontaneous and exploratory movements, and in potentiation of CNS-depressant. A specific blocking action of conditioned response by GNS was significantly confirmed in small doses and did not produce loss of righting reflex, motor incoordination or myo-relaxation. Analgesic, anticonvulsant and antipyretic effects were recognized. From the tests described above in addition to those of traction, hypothermia, fighting behavior and ratio of two reflexes, GNS appears to have neuroleptic activity. There was neither hemolytic nor vasodilator action on the hind leg or coronary vascular beds.

[学科分类] 药理学