EFFECT OF A NEW ANTICHOLINERGIC AGENT (SA-504) ON MOTILITY OF THE GASTROINTESTINAL TRACT AND THE URINARY BLADDER IN CATS

[摘要] References(13)Cited-By(6)Effects of 1, 1-dimethyl-5-methoxy-3-(dithien-2-ylmethylene) piperidinium bromide (SA-504) on the motility of gastrointestinal tract and of the urinary bladder were examined in cats. The inhibitory activity of SA-504 on the spontaneous motility of the stomach brought about by i.v. injection was nearly equal to that of hyoscine-N-butylbromide (HB), but approx. one-fourth of atropine sulfate (Atr). Intragastric administration of either SA-504 or HB produced obvious inhibition on the spontaneous motility of the stomach, while their potencies were less than one-tenth of Atr. The spasmolytic activity of SA-504 on the stomach contraction induced by vagal stimulation was almost equal to that of HB and approx. one-fourth that of Atr. In contrast to the effect on spontaneous motility of the stomach, all these compounds exhibited a somewhat weaker inhibitory action on the contraction of the stomach induced by stimulation. Both SA-504 and HB exhibited more potent inhibition on spontaneous movements of the jejunum and the sphincter of Oddi than on the stomach. On the contrary, the inhibitory potencies of Atr on the jejunum and the sphincter of Oddi did not differ much from those observed in the stomach. The inhibitory effects of these compounds on the contraction of the colon induced by pelvic nerve stimulation was similar to that in the case of stomach contraction induced by vagal stimulation. Inhibition of SA-504 on the spontaneous motility of the urinary bladder was weak and hardly any effect was observed even at a dose inhibiting the gastric motility. HB inhibited the motility of the urinary bladder under the influence of the same dose as that reduced the gastric motility. On the other hand, a significant effect was observed with Air, the activity of which was as strong as on the motility of the stomach. Blockade by these compounds of the contraction of the urinary bladder induced by pelvic nerve stimulation required much higher doses than those required for reduction of spontaneous movements of the bladder. Among the compounds tested, the activity of Atr on the contraction of the urinary bladder was the weakest.

[学科分类] 药理学