EFFECT OF GLUCOSE IN ISOPROTERENOL-INDUCED NECROTIC HEART UNDER ANOXIC PERFUSION

[摘要] References(17)Studies of the isoproterenol-induced necrotic heart perfused under an anoxic condition were performed to determine the changes of metabolism and mechanical function. It was found that the increased concentration of glucose in a perfusion medium enabled the necrotic heart to preserve mechanical functions during anoxia. However, in the normal heart the protective effect of high glucose concentration was not significant. High glucose concentration enhanced anaerobic glycolysis in the necrotic heart during anoxia but had no significant effect on the levels of myocardial high energy phosphates.

[学科分类] 药理学