THE PHARMACOLOGICAL ACTION OF AMINES ON GUINEA PIG SMALL INTESTINE

[摘要] References(47)To seek for the toxic substances in rotten fish which induce vomiting and diarrhea, experiments were carried out with putrescine, agmatine, neurine and tyramine. The following results were obtained : 1. Agmatine and tyramine have no effect on the serosa of the excised intestine of a guinea pig, but 1 mg/ml × 1/50 of neurine induces a contraction of the intestine, and 1 μg/ml × 1/50 of putrescine likewise induces a contraction.2. Putrescine, agmatine and tyramine have no effect on the mucosa of the intestine in vivo, but 10 mg/ml of neurine induces a contraction.3. When each amine is combined with histamine, agmatine is synergistic to the latter by sensibilization; neurine additionally synergistic, while tyramine antagonistic to it. Putrescine does not act on the intestine.

[学科分类] 药理学