Opposite Effects of Calcium and Magnesium on the Central Blood Pressure Regulation in the Spontaneously Hypertensive Rats

[摘要] References(15)Cited-By(1)The effects of intracerebroventricular administration of calcium or magnesium on the blood pressure regulation in the brain were investigated. The systolic blood pressure in spontaneously hypertensive rats (male, 13-week-old) was decreased by calcium chloride (100 μg/rat) and increased by magnesium chloride (20, 100 or 500 μg/rat). The depressor response induced by calcium was inhibited by magnesium chloride in a dose-dependent manner. Combining these results with those previously reported, it is suggested that magnesium inhibits the ability of calcium to reduce blood pressure through calmodulin- and dopamine-dependent functions in the brain.

[学科分类] 药理学

[关键词] Blood pressure in spontaneously hypertensive rats;Calcium/calmodulin-dependent dopamine synthesis;Magnesium