Effects of Histidine on Working Memory Deficits Induced by the 5-HT1A-Receptor Agonist 8-OH-DPAT

[摘要] References(13)Cited-By(6)We investigated the effects of histidine on spatial memory deficits induced by the 5-HT1A-receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Working memory deficits were elicited by 8-OH-DPAT without affecting reference memory. Histidine improved the working memory deficit induced by 8-OH-DPAT at doses causing a significant increase in brain histamine content. This finding suggests that the histaminergic system regulates 8-OH-DPAT-induced working memory deficit.

[学科分类] 药理学

[关键词] Histidine;8-Hydroxy-2-(di-n-propylamino)tetralin;Radial maze performance