Biological Equivalence Between Different Radiotherapy Schedules Studied Using the Linear Quadratic Model

[摘要] The aim of this work was to investigate biological equivalence between different radiotherapy treatment schedules. The first three chapters form an introduction to radiobiological aspects of radiotherapy, these discuss radiation effects on cells and tissues, radiobiological models in radiotherapy and biological equivalence. In chapters 4, 5 and 6 conditions for general equivalence are derived for fractionated, continuous and combined treatments, based on biological effect calculations performed at specific points in a dose distribution. Chapters 7 and 8 introduce the subject of iso-effect surfaces and this concept is applied to both continuous and fractionated treatments. Finally results of this thesis are compared with clinical reports in chapter 9. The Linear Quadratic (LQ) iso-effect model is used in the derivation of general equivalence relationships and in iso-effect surface calculations.

[发布机构] University:University of Glasgow

[关键词] Nuclear physics and radiation, Biophysics