Effects of Nitroglycerin on Stable Thromboxane A2 Analogue-Induced, Nifedipine-Resistant Contraction in Canine Basilar Artery

[摘要] References(15)Cited-By(4)The stable thromboxane A2 analogue, STA2, caused concentrationdependent contractions in the canine basilar artery. In Ca2+-free medium containing EGTA (0.1 mM) and nifedipine (10-6 M), the addition of Ca2+ (2.5 mM) in the presence of STA2 (10-8 M) caused a tonic contraction (nifedipine-resistant Ca2+-induced contraction). In the basilar artery, nitroglycerin did not significantly affect such nifedipine-resistant Ca2+-induced contractions, but nearly abolished the contraction in the coronary artery. The present experiments suggest that the regulatory mechanism of mobilized Ca2+ for the nifedipine-resistant Ca2+-induced contraction produced by STA2 in the basilar artery is different from that in the coronary artery.

[学科分类] 药理学