Carteolol Is a Useful Tool to Prove the Tonically Functioning Nature of Presynaptic β-Adrenoceptors on Peripheral Noradrenergic Neurons but Not on Central Catecholaminergic Neurons

[摘要] References(15)Effects of carteolol on norepinephrine (NE) release were studied at 2 Hz mainly in rat hypothalamic slices. Isoproterenol at 1 and 10 nM concentrationdependently facilitated NE release. Isoproterenol (10 nM)-induced facilitation was antagonized by 1 and 10 nM dl-carteolol, but not antagonized by 1 nM d-carteolol. dl-Carteolol alone at 1 nM to 10 μM did not inhibit NE release. In brainstem slices, 10 nM isoproterenol also facilitated NE release, and this facilitation tended to be antagonized by 1 nM dl-carteolol. Nanomolar concentrations of carteolol stereoselectively antagonized isoproterenol-induced facilitation of NE release via presynaptic β-adrenoceptors in rat hypothalamic slices.

[学科分类] 药理学