Procaine Inhibits Cyclic AMP-Induced Steroidogenesis in Isolated Bovine Adrenocortical Cells

[摘要] References(19)Cited-By(3)Effects of procaine on dibutyryl adenosine 3', 5'-cyclic monophosphate ((Bu)2cAMP)-, Ca2+ or forskolin-induced steroidogenesis were examined in isolated bovine adrenocortical cells. Procaine (<1.0 mM) caused a marked suppression of (Bu)2cAMP or forskolin-induced steroidogenesis in the absence of extracellular Ca2+, but did not affect on Ca2+-induced steroidogenesis in the cells. (Bu)2cAMP decreased the cell associated 45Ca2+. However, procaine (300 μM) inhibited this effect of (Bu)2cAMP. These results suggest that procaine may abolish (Bu)2cAMP-induced Ca2+ release from intracellular calcium store(s) and inhibits steroidogenesis.

[学科分类] 药理学