Evidence for Release of Prostaglandin F2α in Contractile Response of Guinea Pig Trachea to Norepinephrine

[摘要] References(9)Cited-By(5)The concentration (10-8-10-5 M)-;dependent contractile response of norepinephrine was completely inhibited by cyclooxygenase inhibitors but not by a thromboxane synthetase inhibitor. The amount of prostaglandin F2α was significantly increased in the presence of norepinephrine (10-5M). Norepinephrine increased the amount of prostaglandin D2, although not significantly. The norepinephrine-evoked prostaglandin release was inhibited by tolazoline (3×10-5 M). These results suggest that norepinephrine evoked the release of prostaglandins, mainly prostaglandin F2α to induce the contraction of the guinea pig trachea.

[学科分类] 药理学