Effects of Methamphetamine on Regional Cerebral Glucose Utilization in Rats with Unilateral Lesion of Substantia Nigra

[摘要] References(17)Cited-By(2)In rats with electrocoagulation of the unilateral subtantia nigra (SN), methamphetamine at doses of 2.5 and 5 mg/kg, i.p., induced ipsilateral turning towards the lesioned side and caused an imbalance of the regional cerebral glucose utilization (CGU) in the caudate-putamen (CP), frontal cortex (FC) and ventromedial thalamic nucleus (VMT); i.e., showing a higher contralateral CGU as compared with the SN lesioned side. These results induced in unilateral SN-lesioned rats may be accompanied by an imbalance of neural activity in CP, FC and VMT of these rats.

[学科分类] 药理学