The Deleterious Effect of Buthionine Sulfoximine, a Glutathione-Depleting Agent, on the Cisplatin Toxicity in Mice

[摘要] References(16)Cited-By(7)Pretreatment of buthionine sulfoximine (500 mg/kg, i.p., BSO), a potent glutathione-depleting agent, markedly increased the lethality and nephrotoxicity of cisplatin. These results suggest that a reactive electrophilic intermediate may be involved in the mechanism of cisplatin nephrotoxicity and moreover, that renal glutathione may play a protective role against cisplatin-induced nephrotoxicity.

[学科分类] 药理学