Effects of YM-09151-2, a Potent and Selective Dopamine D2 Antagonist, on the Ambulation-Increasing Effect of Methamphetamine in Mice

[摘要] References(11)Cited-By(19)The ambulation-increasing effect of methamphetamine (2 mg/kg, s.c.) was markedly reduced by YM-091 51-2 at 0.01 mg/kg, s.c., in drug-naive mice. The development of reverse tolerance to the ambulation-increasing effect of methamphetamine was also inhibited almost completely when 0.01 mg/kg, s.c., of YM-09151-2 was administered concomitantly in each administration. However, YM-09151-2, at 0.01 mg/kg, was partially suppressed the effect of methamphetamine in mice that exhibited reverse tolerance to methamphetamine.

[学科分类] 药理学