Hyperpolarization-Activated Current Ih in Nucleus of Solitary Tract Neurons: Regional Difference in Serotonergic Modulation

[摘要] References(15)Cited-By(4)The nucleus of solitary tract (NTS) contains diverse neural circuits responsible for basic vital functions. We examined the effect of serotonin (5-HT) on hyperpolarization-activated current (Ih) in neurons acutely isolated from caudal, medial and rostral parts of the NTS. Caudal and medial NTS neurons showed a large amplitude of Ih compared with rostral neurons. In these neurons, perfusion with 5-HT potentiated Ih amplitude in a concentration-dependent manner. The effect of 5-HT was blocked by NAN-190, a 5-HT1A receptor antagonist. Thus, 5-HT1A receptors may regulate Ih channel activity in caudal and medial NTS neurons.

[学科分类] 药理学

[关键词] Nucleus of solitary tract;Hyperpolarization-activated current;Serotonin