Stimulatory Effects of Centrally Injected Nitric Oxide Donors on Gastric Acid Secretion in Anesthetized Rats

[摘要] References(38)Cited-By(1)The effects of centrally injected nitric oxide (NO) donors on gastric acid secretion were investigated in continuously perfused stomach of anesthetized rats. The lateral cerebroventricular (LV) injection of NOC5 (30 – 100 μg) and NOC12 (10 – 100 μg) dose-dependently stimulated gastric acid secretion. The LV injection of NOC18 (30 μg) also stimulated gastric acid secretion. The other type of NO donor, sodium nitroprusside (3 – 30 μg, LV), also dose-dependently stimulated gastric acid secretion. The effect of NOC5 at 100 μg was blocked by carboxy-PTIO, an NO scavenger, and by cervical vagotomy. Furthermore, NOC12 (30, 100 μg) dose-dependently stimulated gastric acid secretion in pylorus-ligated conscious rats. These results suggest that centrally injected NO donors stimulate gastric acid secretion in both conscious and anesthetized rats through vagus activation.

[学科分类] 药理学

[关键词] Nitric oxide donor;Central nervous system;Stomach;Acid secretion