A Nuclear Factor-κB Inhibitor BAY 11-7082 Suppresses Endothelin-1 Production in Cultured Vascular Endothelial Cells

[摘要] References(15)Cited-By(18)BAY 11-7082, an inhibitor of nuclear factor-κB (NF-κB), which prevents a step of the phosphorylation of inhibitory protein IκB bound to NF-κB, suppressed basal and tumor necrosis factor (TNF)-α-induced prepro endothelin (ET)-1 mRNA expression and NF-κB activation in cultured vascular endothelial cells. BAY 11-7082 significantly decreased basal and TNF-α-induced ET-1 release from endothelial cells. These results indicate that the inhibition of NF-κB activation contributes to the suppressive effect of BAY 11-7082 on ET-1 gene expression and ET-1 release, thereby suggesting that NF-κB plays an important role in the regulation of ET-1 production.

[学科分类] 药理学

[关键词] Nuclear factor-κB;Endothelin-1;Tumor necrosis factor-α