Effects of L-765,314, a Selective and Potent α1B-Adrenoceptor Antagonist, on Periarterial Nerve Electrical Stimulation-Induced Double-Peaked Constrictor Responses in Isolated Dog Splenic Arteries

[摘要] References(13)Cited-By(3)The periarterial nerve electrical stimulation (PNS) at a frequency of 1 or 4 Hz (30-s trains of pulses) readily caused a double peaked vasoconstriction in the canine splenic artery. The treatment with 1 μM L-765,314, a selective and potent α1B-adrenoceptor antagonist, markedly inhibited the second peaked constriction, whereas it did not modify the vasoconstrictor responses to exogenous noradrenaline (0.03 – 1 nmol) and A61603 (1 – 30 pmol), a selective α1A-agonist. A large dose of 10 μM L-765,314 significantly blocked exogenous noradrenaline- and A61603-induced responses. It is concluded that PNS-induced responses are mediated via the postjunctional α1B-adrenoceptor subtype.

[学科分类] 药理学

[关键词] L-765;314;Perivascular nerve electrical stimulation;α1-Adrenoceptor subtype