Glutamate Exacerbates Amyloid β1 – 42-Induced Impairment of Long-Term Potentiation in Rat Hippocampal Slices

[摘要] References(15)Cited-By(13)Amyloid β (Aβ) is the principal constituent of senile plaques in Alzheimer’s disease patients. We investigated whether Aβ and glutamate affect long-term potentiation (LTP) in rat hippocampal slices. Pretreatment with 1 μM Aβ1 – 42 alone for 3 h slightly inhibited LTP; however, the potentiation was maintained for 60 min. Although the impairment was not observed by pretreatment with 30 μM glutamate alone for 3 h, pretreatment with Aβ1 – 42 and glutamate impaired LTP significantly. These results raise the possibility that neurotoxicity of Aβ is exacerbated by the enhancement of susceptibility to excitatory amino acids.

[学科分类] 药理学

[关键词] Amyloid β;Long-term potentiation;Glutamate