EXPERIMENTAL STUDIES ON GASTRIC ULCER (4) SEQUENTIAL OBSERVATION AND EVALUATION OF GASTRIC ULCERS BY ENDOSCOPE IN THE RAT

[摘要] References(7)Cited-By(14)In the present study, a sequential observation of the gastric lesions or ulcers in rats weighing from 100 g was made with an endoscope. It was found that bleeding, edema, hyperemia, fur of ulcer and convergences of the mucosal folds in the stomach could be observed in rats with a SES-1717S (φ=1.7 mm) or SES-2217S (φ=2.2 mm) endoscope. Furthermore, we have devised a method which we named the “sohmen method” for measuring ulcer-sizes with an endoscope. The ulcer-size was compared with 5 mm lengths of sohmen (Japanease vermicelli) which were inserted through the sheath of the endoscope into the stomach. Therefore, the ulcer-size could be accurately measured by this method. By this observation method, it is possible to observe repeatedly over a long term the changes in gastric lesions or ulcers, to measure changes in ulcersizes and to evaluate the relapse or recurrence of ulcers in the same rats.

[学科分类] 药理学