An Investigation of the Potential Anti-Tumour Effects of a Tumour Cell-Line Engineered to Secrete Cytokines

[摘要] Systemic administration of cytokines such as IL-2, IL-4 and the interferons have been extensively examined in animal models and clinically to assess their potential as anticancer drugs. To date, the promising results from animal studies have not been reproduced in clinical trials. The systemic administration of cytokines in cancer therapy is also complicated by serious side-effects because of the potency of these compunds. New routes of administering cytokines are therefore being investigated in order to prevent these side-effects and thus allow higher doses of drug to be administered. Routes of administration such as peritumoural, isolated limb perfusion, lymphokine activated killer cells and tumour infiltrating lymphocytes have all been tested clinically with various degrees of success.

[发布机构] University:University of Glasgow

[关键词] Medicine, Bioengineering