Cidofovir effects on recurrent laryngeal papillomatosis in children: preliminary report

[摘要] AIM: To demonstrate the effects of local application of Cidofovir in children with recurrent laryngeal papillomatosis (RLP), according to our 2002 institutional protocol for RLP management.STUDY DESIGN: Preliminary/clinical prospective.MATERIAL AND METHOD: Our series included 5 RLP pediatric patients assisted at the otolaryngology pediatric clinic at the Federal University of Sao Paulo. They were all submitted to local application of Cidofovir and had up to a one-year follow-up. Before starting the treatment with Cidofovir, these patients had been submitted to at least three surgical procedures with histopathological exams confirming the diagnosis of papillomatosis (inclusion criteria); with no clinical evidence of nephropathy or hepatic disorders (exclusion criteria). The protocol consisted of surgical removal of the lesions, followed by local application of 3 ml of Cidofovir (7.5mg/ml). The treatment cycle included minimum of 3 applications, and at any sign of recurrence, another cycle of application would begin. RESULTS: We observed that before the use of Cidofovir, recurrences in all 5 children had shorter intervals (one each three months). After Cidofovir application, the evolution of the illness changed dramatically and the 5 patients did not need any debulking for more than one year. No children presented laboratorial exams alteration, local or systemic collateral effects with local injection of Cidofovir. Based on our preliminary results we observed that local application of Cidofovir in children promotes good short-term control of RLP recurrences.

[学科分类] 医学（综合）

[关键词] laryngeal papillomatosis;cidofovir;HPV virus.