Spectrophotometric method for determination of atazanavir sulfate in capsule dosage form

[摘要] Two sensitive and simple spectrophotmetric methods were developed for determination of Atazanavir Sulfate in capsule dosage form. The first method was based on the oxidative coupling of ATV with 3-Methyl Benzothiazolin-2-one hydrazone (MBTH). The resulting green product had Λmax of 627.3 nm and was stable for 2 h. The second method was based on the reaction between diazotized drug with N-(1-napthyl)ethylenediamine dihydrochloride (NEDA) in neutral medium to yield yellowish orange product which had Λmax of 517.1 nm. The product was stable for 4 h. Both methods were highly reproducible and had been applied to pharmaceutical preparations.

[学科分类] 化学（综合）

[关键词] Atazanavir sulphate;3-Methyl Benzothiazolin-2-one hydrazone;N-(1-napthyl) ethylenediamine dihydrochloride.