Pyrrolizidine alkaloids from Senecio species

[摘要] Senecio species contain a large variety of secondary metabolites and many of these plants afford pyrrolizidine alkaloids. This paper is a review of the literature, describing 62 pyrrolizidine alkaloids already isolated in 62 of more than 2000 species of Senecio, distributed worldwide. The structure-activity relationships involving their toxicity are also discussed, since some Senecio species used for medicinal purposes are responsible for causing serious adverse effects.

[学科分类] 化学（综合）

[关键词] Senecio;pyrrolizidine alkaloids;hepatotoxicity.