Clerodane diterpenes from leaves of Casearia sylvestris Swartz

[摘要] Ethanolic extracts of the leaves of Casearia sylvestris yielded a novel clerodane diterpene, 15-hydroxy-3-cleroden-2-one, together with the known diterpenes (-)-hardwickiic acid, reported for the first time from this species, and casearins B and G, previously isolated from C. sylvestris. The structures of all four compounds were determined by spectrometric analysis. The new clerodane diterpene and (-)-hardwickiic acid contain structural features that are completely different from the highly oxygenated casearins and casearvestrins isolated from C. sylvestris.

[学科分类] 化学（综合）

[关键词] Casearia sylvestris;clerodane diterpenes;15-hydroxy-3-cleroden-2-one.