The predictive value of pre-treatment inflammatory markers in advanced non-small-cell lung cancer

[摘要] BackgroundAccurate prediction of outcome in advanced non-small-cell lung cancer (NSCLC) remains challeng­ing. Even within the same stage and treatment group, survival and response to treatment vary. We set out to determine the predictive value of inflammatory markers C-reactive protein (CRP) and white blood cells (WBCS) in patients with advanced NSCLC. Patients and MethodsPatients were assigned a prognostic index (PI): 0 for CRP 10 mg/L or less and wbcs 11×10 9 /L or less,1 if one of the two markers was elevated, and2 if both markers were elevated. We then used chest computed tomography (CT) imaging to evaluate response after 2 cycles of che­motherapy treatment. ResultsOf 134 patients, 46 had a PI of 0; 60, a PI of 1; and 28, a PI of 2. Disease progressed in 41 patients. Progression was significantly more frequent among patients with a PI of 2 ( p= 0.008). Median survival was 20.0 months for the PI 0 group, 10.4 months for the PI 1 group, and 7.9 months for the PI 2 group ( p p= 0.004). ConclusionsInflammatory state correlates significantly with both chemotherapy response and survival in stage IV NSCLC. The PI may provide additional guidance for therapeutic decision-making.

[学科分类] 肿瘤学