Helicobacter pylori infection predicts favorable outcome in patients with gastric cancer

[摘要] BackgroundRecent studies have suggested a controversial role ofHelicobacter pyloriinfection in gastric cancer prognosis. The aim of the present study was to investigate the potential impact ofH. pyloristatus on the prognosis of patients with gastric cancer in a Chinese prospective cohort. Methods Between 2007 and 2009, 261 patients with curatively resected gastric cancer were enrolled in the study.H. pyloristatus was defined by means of immunohistochemical staining in tumour and non-neoplastic tissues. Treatment prognosis was measured in terms of cancer-specific survival and disease-free survival (dfs). Univariate and multivariate Cox regression models were used to assess the association betweenH. pyloristatus and patient prognosis. Results Positivity forH. pyloriinfection was observed in 188 of the 261 patients (72.0%). In patients positive forH. pylori , m ean c ancer-specific s urvival w as 55.2 months [95% confidence interval (ci): 53.4 to 56.9 months] and mean dfs was 53.9 months (95% ci: 51.8 to 56.0 months); the same survivals were, respectively, 45.1 months (95% ci: 42.2 to 47.9 months) and 43.7 months (95% ci: 40.4 to 47.0 months) in patients negative forH. pylori . In univariate analysis, positiveH. pyloristatus was associated with better cancerspecific survival [hazard ratio (hr): 0.486; 95% ci: 0.271 to 0.870;p= 0.015] and dfs (hr: 0.540; 95% ci: 0.307 to 0.950;p= 0.033). In multivariate analysis,H. pyloriwas an independent prognostic factor for cancer-specific survival (hr: 0.485; 95% ci: 0.265 to 0.889;p= 0.019). Conclusions Our study demonstrates that positiveH. pyloristatus is a beneficial prognostic indicator in patients with gastric cancer and might suggest possible therapeutic approaches for gastric cancer. Further research is required to better understand inflammation mechanisms and cancer progression.

[学科分类] 肿瘤学

[关键词] Helicobacter pylori;gastric cancer;survival;relapse