Relationship between HLA-DRB1 allele polymorphisms and familial aggregations of hepatocellular carcinoma

[摘要] ObjectiveWe explored the relationship betweenHLA-DRB1allele polymorphisms and familial aggregation of hepatocellular carcinoma (fhcc). MethodsPolymerase chain reaction sequence-specific primers were used to determineHLA-DRB1genotypes for 130 members of families with 2 or more liver cancer patients and for 130 members of families without any diagnosed cancers. The genotype profiles were then compared to explore the relationship betweenHLA-DRB1gene polymorphism and fhcc. ResultOf 11 selected alleles, the frequencies ofDRB1 *11 andDRB1 *12 were significantly lower in the fhcc group than in no-cancer group ( p< 0.05; odds ratio: 0.286; 95% confidence interval: 0.091 to 0.901; and odds ratio: 0.493; 95% confidence interval: 0.292 to 0.893). Differences in the frequencies of the other 9 alleles were not statistically significant in the two groups ( p> 0.05). ConclusionsOur research suggests that if genetic factors play a role in fhcc, the deficiency in theDRB1 *11 andDRB1 *12 alleles might be the risk factor at work in Guangxi Zhuang Autonomous Region, P.R.C. 

[学科分类] 肿瘤学

[关键词] HLA-DRB1 alleles;polymorphisms;hepatocellular carcinoma;familial aggregation;pcr-ssp