Problem statement: Mosquito is a very common vector of several tropical diseases such as malaria, filariasis, dengue and chikungunya. Till todate, many xenobiotics have been used to control mosquito population and protect people from mosquito born diseases but increasing rate of resistance against these xenobiotics is a major concern in the disease control management. In contrast, extensive use of these xenobiotic may lead to cause opurtunistic disease like cancer. Therefore, biological control can thus be an effective and environmental friendly approach, which can be used as an alternative to minimize the mosquito population. Fungi and fungus-derived products are highly toxic to mosquitoes, yet have low toxicity to nontarget organisms. Aspergillus niger is a cosmopolitan fungus which is primarily isolated from soil and decomposing plant materials. Approach: In the present investigation, this fungus was cultured on Czapek Dox Broth (CDB) for extracellular metabolites production. The A. niger was maintained at 25
