The breakdown of bilayer lipid membranes by dendrimers

[摘要] The BLM-system for studying the electrophysical properties of bilayer lipid membranes (BLM) was applied to investigate interactions between polyamidoamine (PAMAM) dendrimers and lipid bilayers. The cationic PAMAM G5 dendrimer effectively disrupted planar phosphatidylcholine membranes, while the hydroxyl PAMAM-OH G5 and carboxyl PAMAM G4.5 dendrimers had no significant effect on them.

[学科分类] 分子生物学，细胞生物学和基因

[关键词] PAMAM dendrimer;Planar bilayer lipid membrane;Conductivity;Voltammetry