Arsenic exposure and the seroprevalence of total hepatitis A antibodies in the US population: NHANES, 2003�?2012

[摘要] SUMMARYWe evaluated the association between urinary arsenic and the seroprevalence of total hepatitis A antibodies (total anti-HAV: IgG and IgM) in 11 092 participants aged �?6 years using information collected in the US National Health and Nutrition Examination Survey (2003�?2012). Multivariate logistic regression models evaluated associations between total anti-HAV and total urinary arsenic defined as the sum of arsenite, arsenate, monomethylarsonate and dimethylarsinate (TUA1). Effect modification by self-reported HAV immunization status was evaluated. Total anti-HAV seroprevalence was 35·1% [95% confidence interval (CI) 33·3�?36·9]. Seropositive status was associated with higher arsenic levels and this association was modified by immunization status (P = 0·03). For participants that received �?2 vaccine doses or did not know if they had received any doses, a positive dose-response association was observed between increasing TUA1 and odds of total anti-HAV [odds ratio (OR) 1·42, 95% CI 1·11�?1·81; and OR 1·75, 95% CI 1·22�?2·52], respectively. A positive but not statistically significant association was observed in those who received

[学科分类] 流行病学