Endothelin-A Receptor Antagonists and Advanced Prostate Cancer

[摘要] The endothelin (ET) family consists of 3 peptides—ET-1, ET-2, and ET-3—each of which is composed of 21 amino acids. ETs are potent paracrine/autocrine factors with diverse activity, including modulation of vasomotor tone, nocioception, hormone production, cell proliferation, apoptosis, and stromal formation in a variety of tissues. These effects are predominantly mediated by the action of ET-1 on 2 G protein-coupled ET receptors: ETA and ETB.1,2 In 1993, ET-1 was shown to be produced by benign prostatic epithelial cells and, subsequently, by prostate cancer cells and to play a role in the pathophysiology of prostate cancer progression.3,4

[学科分类] 基础医学