5α-Reductase Inhibition in the Treatment of LUTS and BPH: Update and Importance of Dual Inhibition of Types 1 and 2

[摘要] The articles in this supplement issue of Reviews in Urology illuminate the role of one pivotal metabolic step in the etiology and pathophysiology of benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms (LUTS), and specifically the 2 isoenzymes catalyzing this step: the conversion of the main androgenic steroid testosterone to dihydrotestosterone (DHT) by the 5α-reductase isoenzymes Types 1 and 2.

[学科分类] 基础医学