Pathophysiology of Benign Prostatic Hyperplasia: Insights From Medical Therapy for the Disease

[摘要] The medical treatment of benign prostatic hyperplasia (BPH) has its roots in the early 1970s. During this era, the first clinical trials investigating α-blockade and androgen deprivation therapy were reported for men with clinical BPH. The observation that clinical BPH was improved following administration of both α-blockers and androgen deprivation therapy supported the evolving paradigm that clinical BPH resulted from dynamic and static pathways. During the past several decades, the evolution of α-blockers for the treatment of BPH has been impacted by innovations targeted to simplify the administration and improve tolerability while maintaining their effectiveness.

[学科分类] 基础医学

[关键词] α-Adrenoceptors;α-Blockers;Benign prostatic hyperplasia;Bladder outlet obstruction;Lower urinary tract symptoms;Selectivity